1 DNA Test and Report Package

This foundational test analyses how gene variants can affect food tolerance (and intolerance), appetite control and blood sugar balance, vitamin and mineral needs, detoxification ability, and susceptibility to inflammation and infection.

Metabolism refers to all cellular chemical reactions and is essential for life. It can be divided into ‘anabolism’ (‘build up’ e.g synthesis of sugars, fats, proteins and nucleic acids) and catabolism (‘break down’ e.g., releasing energy in the form of ATP). These processes, and the balance between them, are the key to healthy energy metabolism and cellular function.

The Metabolics Report transforms our understanding of how genes confer metabolic individuality and underpin energy regulation, longevity and healthspan.

Steroid hormones are a group of hormones derived from cholesterol that act as chemical messengers in the body. They are involved in the regulation of many physiological processes in both men and women, such as the development and function of the reproductive system, metabolism, inflammation and immune system.

Methylation is the process of adding methyl groups, consisting of one carbon and three hydrogen atoms, to other molecules. It is involved in almost every metabolic process in the body, occurring billions of times every second in our cells and contributing to numerous crucial functions.

Histamine has many functions: as a neurotransmitter, communicating messages to and from the brain and nervous system; triggering the release of stomach acid to help digestion; and it can also be released after stress, injury or allergic reaction as part of the body’s immune response.

Oestrogen is one of the two major female steroidal sex hormones, the other being progesterone. Men also require oestrogen for producing sperm and maintaining libido, but at significantly lower levels. Oestrogen main role is to increase the growth and production of cells. It is responsible for the development of the female reproductive system and is also involved in maintaining bone density, blood clotting and affects hair, skin, mucous membranes and pelvic muscles.

Detoxification is the physiological removal of toxic substances from the human body. It is mainly carried out by the liver, and to a lesser extent the small intestine, kidneys and lungs. Substances such as nutrients, food additives, pesticides, medications, air pollutants, alcohol and hormones are transformed from being fat-soluble to water-soluble, allowing them to be more easily excreted from the body. The process occurs in two major phases: Phase I primes toxic molecules for deactivation and Phase II finishes the deactivation and prepares for elimination.

The nervous system supports the transmission of messages around the mind and body, enabling an individual to respond to their environment. A neurotransmitter is a molecule that carries signals between neurons and across nerve junctions (synapses). Excitatory neurotransmitters increase the likelihood a neuron will fire a signal, while inhibitory neurotransmitters have the opposite effect. In order for us to interact effectively with our environment these must remain in balance.

The Apolipoprotein E (APOE) gene is best known for its role in lipid (fat) metabolism by helping to remove cholesterol from the bloodstream. It can exist in three main forms known as E2, E3 and E4.

The thyroid is an endocrine gland in the neck that produces two thyroid hormones - triiodothyronine (T3) and thyroxine (T4), and calcitonin. Thyroid hormones control the metabolism of almost every cell in the body, with wide-ranging metabolic, developmental and cardiovascular effects.

DNA sequencing has opened the door to personalised approaches to health and fitness, enabling a more intelligent approach to training, recovery and performance.

In this report, we present elements of your unique DNA profile that have been shown to affect athletic performance.